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Imprinted genes and mental dysfunction.

W Davies1, A R Isles, L S Wilkinson

  • 1Neurobiology and Developmental Genetics Programmes, The Babraham Institute, Cambridge, UK.

Annals of Medicine
|October 5, 2001
PubMed
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Genomic imprinting, a phenomenon where gene expression depends on parental origin, influences common mental disorders. This review explores evidence linking imprinted genes to various mental health conditions.

Area of Science:

  • Genetics
  • Neuroscience
  • Psychiatry

Background:

  • Family, adoption, and twin studies suggest a genetic basis for common mental disorders.
  • Parent-of-origin effects, where inheritance depends on the parent, are observed in some mental disorder transmissions.
  • Genomic imprinting is a genetic mechanism explaining parent-of-origin effects, silencing one gene allele based on its parental source.

Purpose of the Study:

  • To review evidence for the influence of imprinted genes on mental disorders.
  • To examine conditions with explicit imprinted genetic links and those with weaker evidence of parent-of-origin effects.
  • To consider the broader implications of genomic imprinting on mental dysfunction and mammalian brain evolution.

Main Methods:

  • Literature review of genetic studies on mental disorders.

Related Experiment Videos

  • Analysis of evidence for parent-of-origin effects and genomic imprinting.
  • Synthesis of findings related to specific gene candidates and broader evolutionary impacts.

    • Main Results:

    • Evidence suggests imprinted genes contribute to various mental disorders.
    • Some disorders show clear links to imprinted genes, with specific candidates identified.
    • Parent-of-origin effects, explained by genomic imprinting, are a significant factor in mental disorder inheritance.

    Conclusions:

    • Genomic imprinting plays a role in the etiology of common mental disorders.
    • Understanding imprinted genes offers insights into inheritance patterns and potential therapeutic targets.
    • Imprinted gene effects have implications for mammalian brain development, function, and evolution.