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[Morphofunctional changes in the thyroid gland after cyclophosphamide administration and their reversibility]
1Department of Histology, Cytoogy and Embryology, St. Petersburg I.P. Pavlov State Medical University.
Morfologiia (Saint Petersburg, Russia)
|October 6, 2001
Summary
High-dose cyclophosphamide (CY) causes significant, dose-dependent thyroid gland damage, including structural and metabolic alterations. These harmful effects on thyroid function show limited reversibility even after treatment cessation.
Area of Science:
- Histology
- Stereology
- Enzyme Histochemistry
- Thyroid Gland Biology
Context:
- Cyclophosphamide (CY) is a widely used chemotherapy agent.
- Understanding its off-target effects on endocrine organs is crucial.
- The thyroid gland's sensitivity to cytotoxic agents requires investigation.
Purpose:
- To investigate the structural and metabolic impact of short-term, high-dose cyclophosphamide (CY) treatment on the thyroid gland.
- To evaluate the reversibility of CY-induced thyroid changes.
Summary:
- Mice received 400 mg/kg CY every 48 hours for up to 7 days.
- Histological, morphometric, stereological, and enzyme histochemical methods were employed.
- CY induced dose-dependent thyroid changes: thyrocyte damage, follicular wall destruction, altered volume fractions (epithelium decreased, colloid/stroma increased), reduced cell height, and decreased enzyme activities (NAD-H-diaphorase, alkaline phosphatase).
Impact:
- CY causes significant, largely irreversible structural and metabolic damage to the thyroid gland.
- These findings highlight potential endocrine toxicity of high-dose CY therapy.
- Further research into mitigating CY's thyroidal side effects is warranted.