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Nuclear cardiology update.

M D Cerqueira¹, A Lawrence

¹Department of Medicine, Georgetown University Hospital, Washington, DC 20007, USA. cerqm@concentric.net

Radiologic Clinics of North America

|October 6, 2001

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This review covers myocardial perfusion imaging, detailing radiotracer choices, pharmacologic stress agents, and protocols for functional assessment using ECG-gated SPECT. It provides an overview of current options and techniques in cardiac imaging.

Area of Science:

Cardiovascular Imaging
Nuclear Cardiology

Background:

Myocardial perfusion imaging (MPI) is crucial for diagnosing coronary artery disease.
Advances in radiotracer technology and imaging protocols enhance diagnostic accuracy.

Purpose of the Study:

To provide a comprehensive overview of current radiotracer and protocol options in MPI.
To discuss pharmacologic stress agents and their application in MPI.
To highlight the role of ECG-gated single photon emission CT (SPECT) in functional assessment.

Main Methods:

Review of radiotracer selection and optimization for MPI.
Analysis of various pharmacologic stress agents (e.g., adenosine, regadenoson, dobutamine).
Evaluation of ECG-gated SPECT protocols for myocardial perfusion and function.

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Main Results:

Different radiotracers offer varying pharmacokinetic and dosimetric profiles.
Pharmacologic stress testing provides a safe and effective alternative to exercise stress.
ECG-gated SPECT enables accurate assessment of left ventricular volumes, ejection fraction, and wall motion.

Conclusions:

Optimized radiotracer and protocol selection is key for accurate MPI.
Pharmacologic stress agents are valuable tools in MPI, particularly for patients unable to exercise.
ECG-gated SPECT significantly improves the functional assessment capabilities of MPI.