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Updated: Aug 8, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
Published on: February 23, 2014
Selective cricothyroid muscle reinnervation by muscle-nerve-muscle neurotization
H K El-Kashlan1, W R Carroll, N D Hogikyan
1Department of Otolaryngology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0312, USA. hussam@umich.edu
Objective:
To determine if selective reinnervation of the cricothyroid muscle could be achieved with muscle-nerve-muscle neurotization.
Design:
Case series.
Setting:
Tertiary referral center.
Patients:
Three consecutive patients with high vagal lesions that resulted in unilateral laryngeal paralysis.
Interventions:
Patients underwent laryngeal reinnervation with ansa hypoglossi to recurrent laryngeal nerve anastomosis. In addition, patients underwent selective cricothyroid muscle reinnervation by muscle-nerve-muscle neurotization technique.
Main Outcome Measures:
Objective and subjective improvement in voice quality and electromyographic evidence of selective reinnervation of the cricothyroid muscle.
Results:
All patients recovered normal or near-normal speaking voice and had normal objective measures of voice quality. They also showed electromyographic evidence of cricothyroid muscle reinnervation.
Conclusion:
The muscle-nerve-muscle neurotization technique was successful in providing selective reinnervation of the cricothyroid muscle in our 3 patients.
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