Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats

¹Department of Physiology and Pharmacology, The University of Queensland, Qld 4072, Brisbane, Australia.

|October 6, 2001

Summary

Peripheral opioid withdrawal in rats activates brain pathways. Even when opioid antagonists act outside the central nervous system, specific brain regions show increased neuronal activation, indicating a connection.

Area of Science:

Neuroscience
Pharmacology
Neurobiology

Background:

Opioid dependence involves central nervous system (CNS) pathways.
Understanding how peripheral actions influence CNS during opioid withdrawal is crucial.

Purpose of the Study:

To investigate if opioid withdrawal, triggered peripherally, activates brain pathways.
To compare central nervous system (CNS) neuronal activation patterns between peripheral and systemic opioid withdrawal.

Main Methods:

Morphine-dependent rats were used.
Opioid withdrawal was precipitated using naloxone methiodide (peripheral) and naloxone (systemic).
Fos expression, a marker of neuronal activation, was measured in various brain regions.

Main Results:

Peripherally precipitated withdrawal increased Fos expression, but with a more restricted pattern than systemic withdrawal.
Key areas like the locus coeruleus showed no significant activation changes with peripheral withdrawal.
Specific regions, including the ventrolateral medulla and nucleus of the solitary tract, showed similar activation regardless of withdrawal type.

Conclusions:

Peripheral opioid withdrawal can indeed influence central nervous system (CNS) pathways.
The route of opioid antagonist administration impacts the extent and pattern of CNS neuronal activation during withdrawal.

Related Experiment Videos

Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats

Related Concept Videos

A multi-scale vascular atlas of blood vessels within the urinary bladder of male and female mice.

Reliable RNA-seq analysis from FFPE specimens as a means to accelerate cancer-related health disparities research.

Regional Targeting of Bladder and Urethra Afferents in the Lumbosacral Spinal Cord of Male and Female Rats: A Multiscale Analysis.

Identification of a Sacral, Visceral Sensory Transcriptome in Embryonic and Adult Mice.

A single exposure to the tremorgenic mycotoxin lolitrem B inhibits voluntary motor activity and spatial orientation but not spatial learning or memory in mice.

Snap-valve cerebral shunt design for intracranial pressure operation and ultrasound visualization.

Hippocampal teneurin-4 knockdown promotes depression-like behavioral phenotypes by disrupting oligodendrocyte differentiation in mice.

Dual MDM2 and PPARG regulatory axes mediate the antiepileptic effects of Gouteng: An integration of bioinformatics, network pharmacology, machine learning, molecular docking, and MD simulations.

The Positive Feedback Interaction Between Mast Cell-Derived Tryptase and NETs Formation in the Pathogenesis of Sepsis-Associated Encephalopathy.

M3 muscarinic receptor antagonism attenuates cocaine-induced hippocampal oligodendroglial changes and relapse-like behavior in male mice.

Inferior olive-selective amplitude suppression and progressive dentato-cortical decoupling during haloperidol-induced parkinsonism: a longitudinal multi-unit activity study.

Digestion of perineuronal nets in the ventral CA1 suppresses methamphetamine-induced conditioned place preference acquisition by modulating PV interneuron activity in female mice.

Related Experiment Videos

Peripheral withdrawal recruits distinct central nuclei in morphine-dependent rats

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

Related Concept Videos

Related Articles