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Updated: Jul 12, 2026

Examination of Thymic Positive and Negative Selection by Flow Cytometry
14:29

Examination of Thymic Positive and Negative Selection by Flow Cytometry

Published on: October 8, 2012

Downregulated expression of Ly-6-ThB on developing T cells marks CD4+CD8+ subset undergoing selection in the thymus

J T Reese1, H Mehta, C H Chappell

  • 1Department of Cellular Biology, University of Georgia, Athens 30602, USA.

Developmental Immunology
|October 9, 2001
PubMed
Summary

Researchers identified a novel subset of thymocytes (CD4+CD8+ThBneg-low) crucial for T cell selection. Downregulation of Ly-6 ThB protein signals initial thymic selection events in developing T cells.

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