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Screening for mutations of the androgen receptor gene in patients with isolated cryptorchidism
Y Suzuki1, I Sasagawa, J Ashida
1Department of Urology, Yamagata University School of Medicine, Yamagata, Japan.
Objective:
To evaluate the occurrence of mutations of androgen receptor (AR) gene in patients with isolated cryptorchidism.
Design:
Controlled clinical study.
Setting:
Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan.
Patient(S):
Patients with isolated cryptorchidism (n = 48) and a control group of men with normal phenotype (n = 20).
Intervention(S):
Blood (lymphocyte DNA).
Main Outcome Measure(S):
Screening of the AR gene in exons 1-8 using single-strand conformational polymorphism analysis.
Result(S):
No abnormal band patterns were detected in patients with cryptorchidism or in control subjects within the eight exons of the AR gene.
Conclusion(S):
AR gene alterations appear to be an unlikely cause of isolated cryptorchidism.
