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Related Experiment Videos

Optimizing the association between disability and biological markers in MS.

N F Kalkers1, E Bergers, J A Castelijns

  • 1MS-MRI Center, VU Medical Center, Amsterdam, the Netherlands. nf.kalkers@azvu.nl

Neurology
|October 10, 2001
PubMed
Summary

Brain volume measurements on MRI correlate with disability in multiple sclerosis (MS) patients. While early MS disability is linked to lesions, later disability is more associated with overall brain volume loss.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Axonal damage is a key feature of multiple sclerosis (MS) pathology, contributing to progressive disability.
  • Brain volume measurement via MRI serves as a marker for tissue damage and axonal loss in MS.

Purpose of the Study:

  • To investigate the relationship between brain volume measurements and the MS Functional Composite (MSFC).
  • To enhance the clinico-radiologic association in multiple sclerosis research.

Main Methods:

  • 137 MS patients and 12 healthy controls underwent MRI scans.
  • Brain MRI analysis included T1/T2 lesion load, parenchymal fraction (PF), and ventricular fraction (VF).
  • Patients also completed MSFC and Expanded Disability Status Scale (EDSS) assessments.

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Main Results:

  • MS patients exhibited smaller PF and larger VF compared to controls (p < 0.001 for PF, p < 0.01 for VF).
  • Moderate correlations were observed between brain volume metrics (PF, VF) and MSFC scores in patients.
  • Early MS showed correlations with both brain and lesion volume, while late MS correlated only with brain volume.

Conclusions:

  • Brain volume measurements are significantly correlated with MS patient disability, as measured by MSFC.
  • In early MS, focal demyelination is crucial, but in later stages, residual brain volume is a more critical determinant of disability.