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[Collagenous colitis. A study of 11 cases].
1Service de Médecine Interne, GH Pitié-Salpêtrière, 75651 Paris Cedex 13. patrice.cacoub@psl.ap-hop-paris.fr
Annales De Medecine Interne
|October 11, 2001
Summary
Collagenous colitis (CC) is a rare inflammatory bowel disease. This study found CC often presents with extra-digestive symptoms and responds well to sulfasalazine or 5-aminosalicylic acid, with a favorable prognosis.
Area of Science:
- Gastroenterology
- Pathology
- Rheumatology
Context:
- Collagenous colitis (CC) is a rare inflammatory disorder of the large bowel.
- Diagnosis relies on chronic watery diarrhea, normal endoscopic findings, and a subepithelial collagen band >10 micrometers.
- Extra-digestive manifestations and systemic diseases are frequently associated with CC.
Purpose:
- To analyze extra-digestive manifestations in CC patients.
- To identify associated systemic diseases.
- To evaluate the clinical course and treatment response in CC.
Summary:
- This retrospective study analyzed 11 CC patients (10 female, 1 male; mean age 66.6 years) diagnosed between 1989-1999.
- Common extra-digestive findings included arthralgia, weight loss, and autoimmune conditions.
- Sulfasalazine and 5-aminosalicylic acid were effective treatments, with 8/11 patients achieving resolution after a mean follow-up of 18 months.
Impact:
- Highlights the high prevalence of extra-digestive manifestations (36%) in CC.
- Suggests an immune basis for CC due to associations with rheumatic and autoimmune diseases.
- Underscores the importance of colon biopsies for diagnosis and the favorable prognosis with specific therapies.