[Thyroid function after hypofractionated adjuvant radiotherapy for localized breast cancer]

We aimed to evaluate the impact on the thyroid function of hypofractionated adjuvant radiotherapy of localized breast cancer.

This was a prospective study, including 50 patients with breast cancer treated by hypofractionated adjuvant radiation, only half of whom received radiotherapy on the supraclavicular region. The analysis focused on clinical, dosimetric and biological data collected through periodic dosing of thyroid hormones.

The incidence of hypothyroidism was 4% of the patients. The multivariate correlation analysis showed a significant association between initial thyroid volume, volume receiving 50Gy, 40Gy and 30Gy and the incidence of hypothyroidism, no statistical link was found between the bilateral breast, chemotherapy, hormone therapy and the type of surgery and the incidence of radiation-induced hypothyroidism.

Although hypofractionation theoretically exposes the thyroid gland to late radiotherapy complications, radiation-induced dysthyroidism remains a complication underestimated by clinicians, and in the absence of prevention and treatment guidelines, it is necessary to delineate systematically the thyroid gland, to try to minimize as much as possible the doses received by this organ, and to monitor the thyroid function by periodic serum assays.