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Cerebral venous thrombosis in Behçet's disease.
D Saadoun1, B Wechsler, M Resche-Rigon
1Hôpital Pitié-Salpétrière and Pierre et Marie Curie-Paris VI University, Paris, France. david.saadoun@psl.aphp.fr
Arthritis and Rheumatism
|April 1, 2009
Summary
Cerebral venous thrombosis (CVT) affects 7.8% of Behçet's disease (BD) patients, often presenting with extraneurologic lesions. Anticoagulation is a safe and effective treatment for CVT in BD.
Area of Science:
- Neurology
- Rheumatology
- Vascular Medicine
Background:
- Behçet's disease (BD) is a multisystem inflammatory disorder.
- Cerebral venous thrombosis (CVT) is a rare but serious complication of BD.
Purpose of the Study:
- To analyze the clinical characteristics, treatment, and outcomes of CVT in a large cohort of BD patients.
- To determine the prevalence of CVT in BD and identify factors influencing prognosis.
Main Methods:
- A retrospective analysis of 64 consecutive BD patients with CVT.
- Comparison of clinical findings between BD patients with and without CVT.
- Multivariate analysis to identify prognostic factors.
Main Results:
- CVT was present in 7.8% of 820 BD patients.
- CVT patients showed less parenchymal CNS involvement but more extraneurologic vascular lesions.
- Anticoagulation was effective in 90% of cases with no severe hemorrhagic complications.
- Papilledema and concurrent prothrombotic risk factors were associated with sequelae.
- Relapse was linked to prothrombotic factors and peripheral venous thrombosis.
Conclusions:
- CVT in BD can lead to severe neurological outcomes.
- Anticoagulation is a safe and effective treatment for CVT in BD.
- Investigating prothrombotic disorders is crucial in BD patients with CVT.
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