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Cerebral venous thrombosis in Behçet's disease

D Saadoun1, B Wechsler, M Resche-Rigon

  • 1Hôpital Pitié-Salpétrière and Pierre et Marie Curie-Paris VI University, Paris, France. david.saadoun@psl.aphp.fr

Arthritis and Rheumatism
|April 1, 2009
PubMed

Insights

Cerebral venous thrombosis (CVT) affects 7.8% of Behçet's disease (BD) patients, often presenting with extraneurologic lesions. Anticoagulation is a safe and effective treatment for CVT in BD.

Area of Science:

  • Neurology
  • Rheumatology
  • Vascular Medicine

Background:

  • Behçet's disease (BD) is a multisystem inflammatory disorder.
  • Cerebral venous thrombosis (CVT) is a rare but serious complication of BD.

Purpose of the Study:

  • To analyze the clinical characteristics, treatment, and outcomes of CVT in a large cohort of BD patients.
  • To determine the prevalence of CVT in BD and identify factors influencing prognosis.

Main Methods:

  • A retrospective analysis of 64 consecutive BD patients with CVT.
  • Comparison of clinical findings between BD patients with and without CVT.
  • Multivariate analysis to identify prognostic factors.

Main Results:

  • CVT was present in 7.8% of 820 BD patients.
  • CVT patients showed less parenchymal CNS involvement but more extraneurologic vascular lesions.
  • Anticoagulation was effective in 90% of cases with no severe hemorrhagic complications.
  • Papilledema and concurrent prothrombotic risk factors were associated with sequelae.
  • Relapse was linked to prothrombotic factors and peripheral venous thrombosis.

Conclusions:

  • CVT in BD can lead to severe neurological outcomes.
  • Anticoagulation is a safe and effective treatment for CVT in BD.
  • Investigating prothrombotic disorders is crucial in BD patients with CVT.
Abstract

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