Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Late-phase allergy and eustachian tube dysfunction.

S M Hardy1, S B Heavner, D R White

  • 1Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill, 27599-7070, USA. hardys@med.unc.edu

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|October 11, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Johnson Noise <i>Thermometry</i>.

Measurement science & technology·2024
Same author

The Boltzmann project.

Metrologia·2019
Same author

The kelvin redefinition and its mise en pratique.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2016
Same author

From principles to practice: a spatial approach to systematic conservation planning in the deep sea.

Proceedings. Biological sciences·2013
Same author

Electrical substitution radiometry with feedback control: optimization of measurement time and resolution for repeated observations.

Applied optics·2010
Same author

Response time and noise power gain of electrical substitution radiometers with feedback control.

Applied optics·2010
Same journal

Gender-Affirming Care in Otolaryngology: A State of the Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Caffeine Consumption and Rhinologic Symptom Severity.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Preoperative Neutrophil-to-Lymphocyte Ratio Predicts Recurrence in HPV-Associated Oropharyngeal Cancer After Transoral Robotic Surgery.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

PEAK-II Trach: A Multi-Institutional Quality Improvement/Simulation Study Assessing Pediatric Emergency Readiness.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Clinical Features, Treatment, and Outcomes for Oropharyngeal Adenoid Cystic Carcinoma: A Systematic Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same journal

Extended Reality in Otolaryngology-Head & Neck Surgery: A State-of-the-Art Review.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
See all related articles

Late-phase allergy causes Eustachian tube dysfunction, leading to otitis media with effusion. This dysfunction impairs the tube's ability to ventilate and clear the middle ear.

Area of Science:

  • Allergy and Immunology
  • Otolaryngology
  • Pathophysiology

Background:

  • Otitis media with effusion (OME) is a common condition.
  • The role of allergic inflammation in OME pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the impact of late-phase allergic reactions on Eustachian tube function and OME development.

Main Methods:

  • Brown Norway rats were sensitized to ovalbumin.
  • Transtympanic allergen challenge was performed.
  • Eustachian tube ventilatory and mucociliary clearance functions were assessed.

Main Results:

  • Transtympanic allergen exposure induced Eustachian tube dysfunction.
  • Allergic rats showed impaired passive and active pressure clearance.

Related Experiment Videos

  • Mucociliary clearance was significantly reduced in sensitized rats.

    • Conclusions:

    • Late-phase allergy significantly impairs Eustachian tube ventilatory and clearance functions.
    • This impairment leads to the development of otitis media with effusion.