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[Effects of NGF and CNTF on NO level in brain of burn rats]
1Department of Neurobiology, the Second Military Medical University, Shanghai, 200433.
Objective:
To investigate the injurious effects of NO to the brain and protective effect of NGF and CNTF following burn injury in rats.
Methods:
Following intubation of the lateral cerebroventricle, the rats were divided into four groups:sham burn, burn, burn + NGF, burn + CNTF. The contents of NO in various parts of brain in rats with 30% TBSA third degree scald were measured.
Results:
The contents of NO were increased in burned rats. NGF and CNTF could lower the contents of NO.
Conclusion:
The brain injury caused by burns may be associated with increase of NO. The protective effect of NGF and CNTF on the brain of burn rats may be related to lowering of NO.
