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Updated: Jul 15, 2026
A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
Published on: August 8, 2020
[An experimental study of metacresol burn]
Objective:
To study the characteristics of metacresol burn.
Methods:
Metacresol of 99.6% was used. The animals were randomly separated into control group, excision group, topical SD-Ag group, saturated sodium sulfate wet compress group, and warm running water flushing group.
Results:
It was proved that metacresol could not only cause deep burns to skin but also penetrate skin and to produce impairment of functions of the main internal organs of the body, as shown by abnormalities in blood BUN, GPT, GOT, GGT, and AKP. Pathological changes were also found in the liver, heart, brain, kidney, and skin with light and electron microscopy.
Conclusion:
Through comparison of the four different treatment methods for metacresol burns, it is concluded that excision of the wound followed by skin grafting should be done as early as possible to minimize absorption of the chemical. Topical application of SD-Ag or sodium sulfate wet compress, and flushing with running water can alleviate direct injury to skin. Drugs to protect the heart, liver, and kidney should be used for a longer period than usual.
