Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[An initial experiment study on allogenic tissue engineered cartilage].

W Xia1, Y Cao, Q Shang

  • 1Research Center of Tissue Engineering, Shanghai Second Medical University, Department of Plastic Surgery, Ninth People's Hospital, Shanghai 200011, China.

Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery
|October 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Allogeneic hematopoietic stem cell transplantation for RASGRP2 gene-related inherited platelet function disorders: a case report and literature review].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2026
Same author

Preclinical characterization and phase I results of TQB2102, a first-in-class HER2 biparatopic antibody-drug conjugate, in patients with advanced solid tumors.

Annals of oncology : official journal of the European Society for Medical Oncology·2026
Same author

Decoding Spatiotemporal Microenvironmental Changes in Oral Carcinogenesis.

Journal of dental research·2025
Same author

Nutritional impacts of dietary selenium and iodine and their interaction on growth performance, antioxidant capacity and bone quality in Longyan ducklings.

British poultry science·2025
Same author

[A prospective birth cohort study on the association between gestational blood pressure and neurodevelopment in 2-year-old children].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2024
Same author

[Study on the risk factors of coal workers' pneumoconiosis and the mechanism of pyroptosis in peripheral blood].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2024
Same journal

[Analysis of clinical diagnosis and treatment in patients with microtia in Klippel-Feil syndrome].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2018
Same journal

[The anatomic study and clinical application of the premasseter space].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2018
Same journal

[Preparation and evaluation of extracellular matrix scaffold of human adipose tissue].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2018
Same journal

[The application of iTRAQ quantitative proteomics in familial keloid].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2018
Same journal

[Free grafting of big toe nail bed repairing defects of fingernail bed].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2018
Same journal

[Clinical application of orbital fat autograft for tear trough deformity through tranconjunctival approach].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2018
See all related articles

Engineered cartilage can regenerate in allograft animals using tissue engineering. While initial inflammation is present, the novel cartilage matures over time with reduced immune response.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Immunology

Context:

  • Cartilage defects represent a significant clinical challenge.
  • Current treatment options for cartilage repair are limited.
  • Tissue engineering offers a promising approach for cartilage regeneration.

Purpose:

  • To investigate the in vivo formation of engineered cartilage using allogenic chondrocytes.
  • To evaluate the histological and biochemical properties of the regenerated tissue.
  • To assess the host immune response to the engineered cartilage graft.

Summary:

  • Allogenic chondrocytes, combined with Pluronic 127 biomaterial, were implanted subcutaneously in an allograft model.
  • Regenerated cartilage exhibited histological and biochemical characteristics similar to native cartilage.

Related Experiment Videos

  • Inflammatory cell infiltration was observed initially but gradually decreased as the cartilage matured.

    • Impact:

    • This study demonstrates the potential of tissue engineering for cartilage repair in an allograft setting.
    • Understanding the host immune response is crucial for optimizing engineered cartilage survival and function.
    • Further research may lead to improved strategies for treating cartilage damage and osteoarthritis.