Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.9K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.9K
Cancer Prevention02:59

Cancer Prevention

7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.6K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systemic immune-inflammation index and its role in the relationship between subgingival microbiota and periodontal inflammation.

Journal of periodontology·2026
Same author

Oral Pain and Alzheimer's Disease: Prospective Cohort and Cross-Sectional Analyses.

Journal of dental research·2026
Same author

Salivary Metal Ions as Potential Biomarkers for Diabetes: An Observational Study.

International journal of dentistry·2026
Same author

Accelerometer-Derived Rest-Activity Rhythm Amplitude, Genetic Predisposition, and the Risk of Ischemic Heart Disease: Observational and Mendelian Randomization Study.

Journal of medical Internet research·2025
Same author

Epithelial pyroptosis-induced TREM1<sup>+</sup> macrophages activate Th17 cells to accelerate oral mucosal inflammation.

Cell death discovery·2025
Same author

Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2.

Nature communications·2025
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
Same journal

Gingival Fibroblast-Driven Osteoimmunology via the IL-33-ILC2-IL-13 Axis.

Journal of dental research·2026
Same journal

Advancing a Global Oral Health Research Agenda.

Journal of dental research·2026
Same journal

YAP/TAZ Drive Oral Leukoplakia Progression and Confer Ferroptosis Vulnerability.

Journal of dental research·2026
Same journal

Multiancestral GWAS of Dental Malocclusion Identifies Multiple Risk Loci.

Journal of dental research·2026
Same journal

Corrigendum to Redistribution Effect of Demineralized Dentin on Hydrophobic Monomers.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.1K

Decoding Spatiotemporal Microenvironmental Changes in Oral Carcinogenesis.

D Yang1, Z Wang2, Q Shang1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Research Unit of Oral Carcinogenesis and Management, Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of Dental Research
|October 22, 2025
PubMed
Summary
This summary is machine-generated.

Oral carcinogenesis involves changes in the tumor microenvironment. Regulatory B cells (Bregs) interact with IGFBP2-high oral epithelial progenitor cells (OEPCs) via TGF-β signaling, driving early cancer development.

Keywords:
disease progression B-Lymphocytesleukoplakia oralmouth mucosaregulatorystem cellstransforming growth factor beta1

More Related Videos

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.9K
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.6K

Related Experiment Videos

Last Updated: Jan 14, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

12.1K
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

3.9K
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.6K

Area of Science:

  • Oncology
  • Immunology
  • Cell Biology

Background:

  • Oral carcinogenesis is a multistage process involving epithelial changes and critical microenvironment alterations.
  • Understanding these dynamic microenvironmental shifts is key to preventing oral cancer progression.

Purpose of the Study:

  • To investigate microenvironment remodeling during oral mucosa carcinogenesis using multi-omics spatiotemporal analysis.
  • To identify key cellular players and signaling pathways involved in oral cancer development.

Main Methods:

  • Multi-omics spatiotemporal analysis of oral mucosa during carcinogenesis.
  • Identification and characterization of oral epithelial progenitor cells (OEPCs) and regulatory B cells (Bregs).
  • Spatial transcriptomics to confirm cell proximity and interactions via the TGF-β signaling pathway.

Main Results:

  • A subset of OEPCs with high Insulin-like Growth Factor Binding Protein 2 (IGFBP2) expression was identified, showing increased proliferation and reduced differentiation.
  • Increasing infiltration of Bregs was observed during precancerous stages, interacting with IGFBP2-high OEPCs through TGF-β signaling.
  • Breg infiltration plateaued or declined in advanced cancer, suggesting stage-specific regulatory mechanisms.

Conclusions:

  • The study reveals the evolution of the oral cancer microenvironment, highlighting the role of Bregs and IGFBP2-high OEPCs.
  • The interaction between Bregs and OEPCs via TGF-β signaling contributes to disrupted cellular balance and potential malignancy.
  • Focusing on precancerous stages is crucial for understanding and potentially intervening in oral carcinogenesis.