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Nickel-promoted alkylative or arylative carboxylation of alkynes
M Takimoto1, K Shimizu, M Mori
1Graduate School of Pharmaceutical Scieneces, Hokkaido University, Sapporo 060-0812, Japan.
Organic Letters
|October 12, 2001
Abstract:
[reaction: see text]. Nickel-promoted alkylative or arylative carboxylation of terminal alkynes via a carbon dioxide fixation process was investigated. In the presence of a stoichiometric amount of a zero-valent nickel complex, the reaction of alkynes with CO2 gave a nickelacycle, which was reacted with various organozinc reagents under very mild conditions to provide beta,beta'-disubstituted, alpha,beta-unsaturated carboxylic acids in a highly regio- and stereoselective manner.