Related Experiment Video
Updated: Oct 4, 2026
Fabrication and Surgical Application of Enriched Photo-crosslinked Gelatin–Riboflavin Hydrogels for Corneal Wound Repair in Rabbits
Published on: April 24, 2026
Influence of laser irradiation on endogenous hyaluronan in rabbit iris and aqueous humor
A Koralewska-Makár1, C Johnsson, A Bruun
1Department of Ophthalmology, University of Lund, Sweden. Anna.Makar@oft.lu.se
Purpose:
To monitor changes of endogenous hyaluronan in the iris tissue and aqueous humor after an isolated trauma to the iris by argon laser irradiation of the anterior surface of the iris.
Methods:
Iris and aqueous hyaluronan concentrations in rabbit were measured with a radiometric assay at different time points after laser irradiation.
Results:
Total hyaluronan content in iris tissue increased 3-fold to a peak concentration of 71-72 microg/g at 1 and 2 days after laser treatment. Aqueous hyaluronan increased to a maximum of about 1.6 microg/ml at 2 h and 12 h after laser irradiation of the iris.
Conclusions:
The iris tissue responds with increased hyluronan synthesis to an isolated iris argon laser irradiation and it seems to be the most important source of aqueous hyaluronan.
