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Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons
K J Burman1, D J McKitrick, J B Minson
1Cardiovascular Neuroscience Group, Cardiovascular Medicine and Centre for Neuroscience, Flinders University of South Australia, South Australia 5042, Bedford Park, Australia. kathy.burman@flinders.edu.au
Abstract:
Substance P activation of neurokinin-1 (NK1) receptors on spinal sympathetic preganglionic neurons (SPN) influences blood pressure. We identified SPN likely to subserve the baroreceptor reflex and established if these neurons showed NK1 receptor-immunoreactivity. Nitroprusside (NP) infusion or inferior vena cava (IVC) constriction activated similar numbers of SPN. Of these, about 40% were NK1 receptor-immunoreactive after NP infusion, but only about 20% were NK1 receptor-immunoreactive after IVC constriction. The distribution of Fos/NK1 receptor SPN suggested that substance P may preferentially target sympathoadrenal SPN.