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Related Experiment Videos

No decrease in free IGF-I with increasing insulin in obesity-related insulin resistance.

W Ricart1, J M Fernández-Real

  • 1Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona, Spain. endocrino@htrueta.scs.es

Obesity Research
|October 12, 2001
PubMed
Summary
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Obesity alters how the body regulates free insulin-like growth factor-I (IGF-I) and IGF-binding protein-1 (IGFBP-1). Insulin resistance in obesity prevents the normal suppression of free IGF-I after glucose administration.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Obesity Studies

Background:

  • The insulin-like growth factor (IGF)/IGF-binding protein (IGFBP) system is crucial for glucose metabolism.
  • The role of free IGF-I in glucose homeostasis within insulin resistance is not well understood.
  • Growth hormone is not the only factor regulating the IGF/IGFBP system.

Purpose of the Study:

  • To investigate the impact of acute glucose and insulin level changes on free IGF-I and IGFBP-1.
  • To compare these effects in obese versus non-obese individuals.

Main Methods:

  • Nineteen lean and 24 obese subjects participated.
  • A frequently sampled intravenous glucose tolerance test was administered.
  • Plasma concentrations of free IGF-I and IGFBP-1 were measured at multiple time points.

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Main Results:

  • Obese subjects had higher basal free IGF-I and lower IGFBP-1 levels compared to lean subjects.
  • Insulin administration significantly suppressed free IGF-I in lean subjects but not in obese subjects.
  • IGFBP-1 suppression was similar in both groups following insulin administration.

Conclusions:

  • Obesity differentially regulates free IGF-I and IGFBP-1 concentrations.
  • Obesity-related insulin resistance is associated with unsuppressed free IGF-I levels.