[ Studies on some physical characteristics of cyclosporine A (CyA) solid dispersions]

In this paper, poloxamer and PVP were used as carriers. CyA-poloxamer and CyA-PVP solid dispersions were prepared using the melting-solvent method or solvent method, respectively. The percentage compositions of the solid dispersions ranged from 10:90 to 90:10. Hot stage microscopy, powder X-ray diffraction and differential scanning calorimetry were used to examine the physical-chemical characteristics of the solid dispersions to provide some reliable and scientific basis for preformulation of CyA.