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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
Diabetes mellitus and the stomach
1Psychophysiology Unit, Department of Surgery, University of Vienna, Austria. georg.stacher@akh-wien.ac.at
Diabetologia
|October 13, 2001
Summary
Diabetic patients often experience gastric issues due to motor dysfunction, impacting blood sugar control. Autonomic neuropathy is a key factor, though treatments to improve gastric emptying show limited long-term success.
Area of Science:
- Gastroenterology
- Endocrinology
- Diabetology
Background:
- Diabetes mellitus (Type I and Type II) frequently causes early satiety and postprandial gastric fullness.
- These symptoms stem from gastric motor dysfunction, leading to unpredictable nutrient absorption and blood glucose fluctuations.
- Approximately 50% of diabetic patients are affected by this condition.
Purpose of the Study:
- To critically review current data on impaired gastric motor function in diabetes mellitus.
- To explore the role of hyperglycemia and autonomic neuropathy in diabetic gastric dysfunction.
- To assess the potential of prokinetic drugs for improving glycemic control.
Main Methods:
- Literature review of studies investigating gastric emptying in diabetic patients.
- Analysis of the relationship between hyperglycemia, autonomic neuropathy, and gastric motor function.
- Evaluation of clinical trial data on drugs aimed at enhancing gastric emptying.
Main Results:
- Gastric emptying is slower in hyperglycemic states compared to euglycemic states.
- Cardiovascular autonomic neuropathy severity correlates with impaired gastric emptying, independent of glycemic levels.
- Therapeutic interventions to reduce blood glucose did not consistently improve gastric emptying rates.
Conclusions:
- Impaired gastric motor function is a significant contributor to poor glycemic control in many diabetic individuals.
- Diabetic autonomic neuropathy is identified as the primary underlying cause of gastric dysfunction.
- Current evidence on the long-term efficacy of prokinetic drugs for this condition is limited and largely negative.
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