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Shetland Sheepdog leukodystrophy.

S L Wood¹, J S Patterson

¹Department of Small Animal Clinical Sciences, Michigan State University Veterinary Teaching Hospital, East Lansing, USA. sheridanwood@aol.com

Journal of Veterinary Internal Medicine

|October 13, 2001

Summary

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A familial leukodystrophy causing neurological dysfunction was identified in Shetland Sheepdog pups. This inherited condition, resembling Canavan disease, affects the brain and spinal cord

Area of Science:

Veterinary Neurology
Canine Genetics
Neurobiology

Background:

Investigated a familial neurological disorder in Shetland Sheepdog litters characterized by seizures and progressive dysfunction.
Suspected an inherited basis for the observed neurological syndrome in affected pups.

Observation:

Nine pups across three litters exhibited severe, diffuse spongy degeneration of the brain and spinal cord white matter.
Computed tomography revealed diffuse hypomyelination in affected individuals.

Findings:

Postmortem examinations, including histopathology and electron microscopy, identified a leukodystrophy similar to human Canavan disease.
Standard metabolic and biochemical screening tests did not reveal abnormalities in amino acid or organic acid metabolism.
The specific etiology for this Shetland Sheepdog leukodystrophy remains undetermined.

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Implications:

This study highlights a novel inherited leukodystrophy in the purebred dog population.
Further research is needed to elucidate the genetic and molecular basis of this canine neurological disease.
Understanding this condition may offer insights into human leukodystrophies like Canavan disease.