Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early brain wiring: activity-dependent processes.

A A Penn1

  • 1Lucile Packard Children's Hospital, Stanford University School of Medicine, CA, USA. apenn@stanford.edu

Schizophrenia Bulletin
|October 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental contribution to neonatal encephalopathy.

Seminars in fetal & neonatal medicine·2021
Same author

Decision making for seriously compromised newborns: the importance of exploring cultural differences and unintended consequences.

Journal of perinatology : official journal of the California Perinatal Association·2013
Same author

Effect of magnesium sulfate exposure on term neonates.

Journal of perinatology : official journal of the California Perinatal Association·2012
Same author

Global hormone profiling of murine placenta reveals Secretin expression.

Placenta·2011
Same author

Perspectives of recent trainees on career choices in neonatology.

Journal of perinatology : official journal of the California Perinatal Association·2006
Same author

Brain waves and brain wiring: the role of endogenous and sensory-driven neural activity in development.

Pediatric research·1999
Same journal

Metabolic Improvements with a Ketogenic Diet Correlate with Symptom Improvement in Psychosis: A Randomized Controlled Trial.

Schizophrenia bulletin·2026
Same journal

Reconsidering the Term "Treatment Resistant Schizophrenia".

Schizophrenia bulletin·2026
Same journal

The Effect of Semaglutide on Antipsychotic-Induced Weight Gain and Other Metabolic Parameters, among a Cohort of Inpatients.

Schizophrenia bulletin·2026
Same journal

Comparing Apples to Oranges Obscures Tortoises Beating Hares: The Relationship Between Rate of Antipsychotic Tapering and Relapse.

Schizophrenia bulletin·2026
Same journal

Beyond the Need for Speed: D2 Receptor Affinity Predicts Relapse after Antipsychotic Tapering in First Episode Psychosis.

Schizophrenia bulletin·2026
Same journal

Correction to: The Mini-CAARMS: Development and Validation of a Short Version of the Comprehensive Assessment of AT Risk Mental States to Facilitate Preventive Psychiatry.

Schizophrenia bulletin·2026
See all related articles

Neural activity, both sensory-driven and endogenous, shapes brain circuits during development. Understanding this activity-dependent neural development is key to exploring schizophrenia

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Neurobiology

Background:

  • Schizophrenia is theorized to stem from developmental issues in neural connectivity.
  • Precise neural connections are essential for normal brain function.
  • Both sensory-driven and endogenous neural activity are vital for establishing these connections.

Purpose of the Study:

  • To review principles of activity-dependent neural development.
  • To illustrate the role of patterned activity, neuronal competition, and critical periods.
  • To explore potential links to schizophrenia etiology.

Main Methods:

  • Summarizing basic neuroscience experiments, particularly in the mammalian visual system.
  • Reviewing established principles of neural circuit formation.

Related Experiment Videos

  • Discussing molecular mechanisms underlying activity-dependent development.

    • Main Results:

    • Patterned neural activity is crucial for sculpting precise neural circuits.
    • Endogenous neural activity plays a significant role before sensory input.
    • Neuronal competition and critical periods are key features of this developmental process.

    Conclusions:

    • Activity-dependent neural development shapes complex brain functions.
    • Understanding these developmental processes may offer insights into schizophrenia.
    • Further research into molecular mechanisms is warranted.