Related Experiment Videos
An enantioselective synthesis of insecticidal 4-alkynyloxazolines
1DuPont Crop Protection, Stine/Haskell Research Center, PO Box 30, Bldg 300, Newark, DE 19714, USA. david.a.clark@usa.dupont.com
Bioorganic & Medicinal Chemistry
|October 13, 2001
Abstract:
2-(2,6-Difluorophenyl)-4-phenylalkynyl oxazolines are potent insect growth regulators. An efficient and enantioselective synthesis to these compounds has been developed which relies on a (-)-sparteine mediated hydroxymethylation of the lithium dianion of propargylic amides.