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Upstream mediators of the Fas apoptotic transduction pathway are defective in B-chronic lymphocytic leukemia
1UPRES-EA 2128, UFR de Médecine, Université de Caen, CHU Côte de Nacre, 14032 Cedex, Caen, France.
Abstract:
Data concerning the presence and the functionality of Fas receptor in malignant B-cells are controversial. We have analyzed Fas molecules on B-cells from patients with B-chronic lymphocytic leukemia (B-CLL) cells. We observed a large variability, both of percentage of Fas-positive cells and of intensity of Fas level. Fas triggering was inefficient in inducing apoptosis whatever the number of Fas-positive B-cells, the amount of Fas receptors. B-cells were also resistant to etoposide treatment, but able to undergo apoptosis after dexamethasone treatment. We suggest that the Fas apoptotic pathway is altered in B-CLL patients at the initial step(s) of apoptotic machinery.
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