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[Inhibition of beta-amyloid precursor protein gene expression by haifengteng]
1Department of Neurology, Affiliated Hospital of Shandong Medical University, Jinan 250012.
Abstract
Objective:
To study the inhibition of beta-amyloid precursor protein(beta-APP) gene expression by Haifengteng.
Method:
Northern Blot analysis was used to investigate the level of beta-APP mRNA, and cell viability, LDH-release and colony formation assay were used to study the effect of Hairengteng of neurons.
Result:
Haifengteng inhibited the expression of beta-APP gene selectively without causing cell injuries.
Conclusion:
beta-APP is closely related to Alzheimer's disease. The findings in this study could be a basis for Haifengteng to have therapeutic potentials in treating Alzheimer's disease.