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Related Experiment Videos

Free radical scavenging active components from Cedrus deodara.

A K Tiwari1, P V Srinivas, S P Kumar

  • 1Division of Pharmacology and Natural Product Laboratory and Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India.

Journal of Agricultural and Food Chemistry
|October 16, 2001
PubMed
Summary

Researchers identified potent antioxidant compounds from Cedrus deodara heartwood. These compounds, including (-)-matairesinol and (-)-nortrachelogenin, show significant free radical scavenging activity.

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Pharmacognosy

Background:

  • Cedrus deodara (Deodar cedar) is a tree species with a history of traditional medicinal use.
  • Identifying bioactive compounds from medicinal plants is crucial for drug discovery and understanding their therapeutic potential.
  • Antioxidants play a vital role in combating oxidative stress, implicated in numerous diseases.

Purpose of the Study:

  • To isolate and identify antioxidant compounds from the heartwood of Cedrus deodara.
  • To evaluate the antioxidant activity of the isolated compounds.
  • To report novel occurrences of specific lignans in C. deodara.

Main Methods:

  • Activity-directed fractionation of Cedrus deodara heartwood extract.
  • Extraction using petroleum ether and chloroform.

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  • Purification via silica gel column chromatography.
  • Spectroscopic identification (1H NMR, 13C NMR, IR, MS).

    • Main Results:

    • The chloroform extract exhibited significant antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals.
    • Three potent antioxidant compounds were isolated: (-)-matairesinol, (-)-nortrachelogenin, and a dibenzylbutyrolactollignan (4,4',9-trihydroxy-3,3'-dimethoxy-9,9'-epoxylignan).
    • This marks the first documented identification of these specific lignans in Cedrus deodara.

    Conclusions:

    • Cedrus deodara heartwood contains potent antioxidant lignans.
    • The isolated compounds (-)-matairesinol, (-)-nortrachelogenin, and the novel dibenzylbutyrolactollignan possess significant DPPH free radical scavenging activity.
    • This study contributes to the phytochemical understanding of Cedrus deodara and highlights its potential as a source of natural antioxidants.