Related Experiment Video

Updated: Oct 4, 2026

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
07:34

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis

Published on: December 30, 2025

Acute fulminant fungal sinusitis: clinical presentation, radiological findings and treatment

M A Sohail1, M Al Khabori, J Hyder

  • 1ENT Department, Al Nahdha Hospital, P.O. Box 937, Postal Code 112, Sultanate of Oman, Oman.

Acta Tropica
|October 16, 2001
PubMed

Insights

Acute fulminant fungal sinusitis is a severe condition with high mortality and significant disability. Early recognition and treatment in at-risk populations are crucial for improving outcomes.

Area of Science:

  • Otolaryngology
  • Infectious Diseases
  • Pathology

Background:

  • Acute fulminant fungal sinusitis presents with rapid progression and high mortality (60-80%).
  • Survivors often experience permanent neurological, visual, and cosmetic deficits.
  • Increasing incidence is expected due to rising numbers of at-risk individuals (diabetics, AIDS, immunosuppressed).

Purpose of the Study:

  • To review nine cases of acute fulminant fungal sinusitis.
  • To determine common clinical presentations and radiological findings.
  • To evaluate optimal treatment strategies and patient outcomes.

Main Methods:

  • Retrospective review of nine patient cases.
  • Analysis of clinical presentation, radiological data, and treatment regimens.
  • Diagnosis confirmed via biopsy and culture of affected tissues (sinus mucosa, cheek, orbit).

Main Results:

  • Common symptoms included fever, headache, facial swelling, and proptosis.
  • Presenting complications included blindness, facial paralysis, and meningitis.
  • Predisposing factors included uncontrolled diabetes, post-transplant immunosuppression, and leukemia.
  • Mucor (Zygomycetes) was identified in all cases.
  • Six of nine patients survived; only two had no permanent disability.

Conclusions:

  • Early recognition and prompt treatment are vital for managing acute fulminant fungal sinusitis.
  • Aggressive management, including antifungal therapy (Amphotericin B) and surgical debridement, is necessary.
  • High morbidity persists even with survival, highlighting the need for improved diagnostic and therapeutic approaches.

Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...