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Related Experiment Videos

Electroanalysis of dapsone, an anti-leprotic drug.

P Manisankar1, A Sarpudeen, S Viswanathan

  • 1Department of Industrial Chemistry, Alagappa University, Karaikudi-630 003, India. pms11@rediffmail.com

Journal of Pharmaceutical and Biomedical Analysis
|October 16, 2001
PubMed
Summary
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Electrochemical methods effectively detected dapsone, an anti-leprotic drug, in pharmaceutical tablets and biological samples. This study optimized conditions for sensitive and reliable dapsone quantification.

Area of Science:

  • Electrochemistry
  • Analytical Chemistry

Background:

  • Dapsone is a crucial anti-leprotic medication.
  • Sensitive analytical methods are needed for dapsone determination in various matrices.

Purpose of the Study:

  • To investigate the electrochemical oxidation and adsorption of dapsone.
  • To develop and optimize an electrochemical method for dapsone quantification.

Main Methods:

  • Cyclic voltammetry and controlled potential coulometry were employed.
  • Square-wave stripping voltammetry was optimized for sensitivity.
  • Electrochemical analysis was performed using a glassy carbon electrode in an aqueous alcohol medium.

Main Results:

  • Dapsone exhibited irreversible, diffusion-controlled adsorption with one-electron oxidation.

Related Experiment Videos

  • Optimized square-wave stripping voltammetry achieved a low limit of determination (0.0036 mg/ml).
  • The method demonstrated high precision with a relative standard deviation of 0.4%.

    • Conclusions:

    • An efficient electrochemical method for dapsone determination was successfully developed.
    • The method is suitable for quantifying dapsone in pharmaceutical formulations and biological samples like urine.
    • This technique offers a sensitive and reliable approach for dapsone analysis.