Related Experiment Videos
Electroanalysis of dapsone, an anti-leprotic drug
P Manisankar1, A Sarpudeen, S Viswanathan
1Department of Industrial Chemistry, Alagappa University, Karaikudi-630 003, India. pms11@rediffmail.com
Journal of Pharmaceutical and Biomedical Analysis
|October 16, 2001
Summary
Electrochemical methods effectively detected dapsone, an anti-leprotic drug, in pharmaceutical tablets and biological samples. This study optimized conditions for sensitive and reliable dapsone quantification.
Area of Science:
- Electrochemistry
- Analytical Chemistry
Background:
- Dapsone is a crucial anti-leprotic medication.
- Sensitive analytical methods are needed for dapsone determination in various matrices.
Purpose of the Study:
- To investigate the electrochemical oxidation and adsorption of dapsone.
- To develop and optimize an electrochemical method for dapsone quantification.
Main Methods:
- Cyclic voltammetry and controlled potential coulometry were employed.
- Square-wave stripping voltammetry was optimized for sensitivity.
- Electrochemical analysis was performed using a glassy carbon electrode in an aqueous alcohol medium.
Main Results:
- Dapsone exhibited irreversible, diffusion-controlled adsorption with one-electron oxidation.
- Optimized square-wave stripping voltammetry achieved a low limit of determination (0.0036 mg/ml).
- The method demonstrated high precision with a relative standard deviation of 0.4%.
Conclusions:
- An efficient electrochemical method for dapsone determination was successfully developed.
- The method is suitable for quantifying dapsone in pharmaceutical formulations and biological samples like urine.
- This technique offers a sensitive and reliable approach for dapsone analysis.