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Related Experiment Videos

[Calcium ions and the nervous system plasticity].

P G Kostiuk1

  • 1Bogomoletz Institute of Physiology, Ukraine, 252024, Kiev, Bogomoletz St., 4.

Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
|October 17, 2001
PubMed
Summary

The nervous system

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Physiology

Context:

  • The nervous system exhibits remarkable flexibility.
  • Plasticity is a key feature of neuronal function.
  • Intracellular calcium ions (Ca2+) play a crucial role.

Purpose:

  • To review the mechanisms of intracellular Ca2+ in neural plasticity.
  • To explore Ca2+ signaling in developmental, mature, and aging nervous systems.

Summary:

  • Changes in free calcium ions (Ca2+) in the cytosol are central to nervous system plasticity.
  • Calcium signals activate intracellular pathways that modify neuronal structure and function throughout life.
  • This review details Ca2+ mechanisms underlying developmental plasticity, synaptic plasticity, and age-related decline in plasticity.

Impact:

  • Provides a comprehensive overview of calcium's role in neural plasticity.
  • Highlights the molecular basis of lifelong learning and memory.
  • Informs research on neurodegenerative diseases and aging.

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