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Updated: Jul 28, 2026

Recapitulation of an Ion Channel IV Curve Using Frequency Components
Published on: February 9, 2011
[Role of changes in the transmembrane ion currents in pathological states of the body]
1International Center of Molecular Physiology, A.A. Bogomolec Institute of Physiology Ukrainian NAS, Kiev.
Abstract:
Modern data of study of transmembrane ions currents (through the sodium-potassium- and calcium-channels) in the mechanism of pathological pain syndromes were reviewed. Tetrodotoxyn-resistant sodium currents, abnormal combinations of different types of sodium-channels during the inflammation, neuropathies (syndromes hyperalgesii and allodonii) and diabetic neuropathy analyzed. The role of pain sensitivity transmitters was demonstrated. Nerve Grow Factor plays the important role in the sodium-channels genes expression. Different types of transmembrane calcium currents participated in hyperalgesium and hypoalgesium analyzed. The summary mechanism of pain suggested as voltage-calcium-channels activation and transsynaptic NMDA receptors excitation that should be conductive the neurons hyperexcitation and force of synaptic transmission.
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