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Published on: February 10, 2013
Evaluation of cardiac beta-adrenergic receptor function in children by dobutamine stress echocardiography
1Department of Pediatrics, First Teaching Hospital of Beijing Medical University, Beijing 100034, China.
Objective:
To investigate the role of dobutamine stress echocardiography in evaluating cardiac beta-adrenergic receptor (beta-AR) function and responsiveness in children.
Methods:
Left ventricular ejection fraction (EF), fractional shortening (FS), left ventricular end systolic volume index (ESVI), the ratio of systolic blood pressure and ESVI (SP/ESVI) were measured by dobutamine stress echocardiography (DSE) in 30 children with beta-AR hypersensitivity, 15 children with dilated cardiomyopathy and 30 normal children respectively.
Results:
Before pharmacological stress, EF and FS were 0.72 and 0.39 respectively in beta-AR hypersensitivity group versus 0.70 and 0.35 respectively in control group. There was no difference of the indices between the two groups (P > 0.05). SP/ESVI was 0.76, higher than the value of 0.66 in control group (P < 0.05); EF, FS and SP/ESVI were 0.41, 0.15 and 0.10 respectively, which were significantly lower than those in control group. After dobutamine stress of 5 micrograms.kg-1.min-1 and 10 micrograms.kg-1.min-1, EF, FS and SP/ESVI were significantly increased in patients with beta-AR hypersensitivity and there were no changes in children with dilated cardiomyopathy compared with values of baseline.
Conclusion:
Cardiac beta-AR function and responsiveness can be evaluated by dobutamine stress echocardiography.
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