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Published on: September 26, 2011
Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998
V Chiţu1, C C Diaconu, D Veliceasa
1HIV/AIDS Department, St. S. Nicolau Institute of Virology, Bucharest, Romania.
This study tracked human immunodeficiency virus type 1 (HIV-1) subtypes in adults in Bucharest from 1992-1998. Serotype F predominated, with a slight increase in serotype B and minimal serotype E, suggesting potential new subtype emergence.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Human immunodeficiency virus type 1 (HIV-1) exhibits significant genetic and phenotypic variability.
- Geographic location and transmission routes influence HIV-1 subtype distribution.
- Limited data exists on HIV-1 subtype distribution among adult populations in Romania, particularly in Bucharest.
Purpose of the Study:
- To investigate the temporal changes in HIV-1 subtype distribution among adult patients in Bucharest.
- To analyze the prevalence of different HIV-1 serotypes over a six-year period (1992-1998).
Main Methods:
- Utilized V3 binding assays for HIV-1 serotyping.
- Analyzed viral samples from adult HIV-1 infected patients in Bucharest.
- Conducted a longitudinal study over six years (1992-1998).
Main Results:
- Serotype F consistently predominated, accounting for 50-75% of cases throughout the study period.
- A gradual increase in serotype B was observed, rising from 5% in 1994 to 14% in 1998.
- Serotype E was rarely detected (4%), and a notable proportion of samples (6-30%) were non-reactive, possibly indicating novel or recombinant subtypes.
Conclusions:
- Serotype F remains the dominant HIV-1 subtype in adult populations in Bucharest.
- The increasing prevalence of serotype B and the presence of non-reactive samples warrant further investigation into emerging HIV-1 strains.
- Continued surveillance of HIV-1 subtypes is crucial for understanding transmission dynamics and informing public health strategies.
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