Cell biology of precancer

This article explores the possibilities of understanding the natural history of human cancers. In particular it attempts to understand precancer in cell biological or molecular rather than clinical or pathological terms. The questions discussed on the relevance of precancer in the neoplastic development are: are all cancers preceded by precancer? Is a precancer in the cell lineage characterised by hypermutability? Is there a direct DNA lineage from precancer to cancer? How many mutations have been added as a function of a number of DNA generations in the process to neoplastic transformation? Is precancer reversible? Can analysis of precancer provide a short cut to assessment of carcinogenic risk? The present data addressing these questions are discussed and the still unexplained phenomena are highlighted.