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Tetrandrine inhibits inward rectifying potassium current in cultured bovine aortic endothelial cells
1Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
Aim:
To study the effect of tetrandrine (Tet) on inward rectifying potassium current in cultured bovine aortic endothelial cells.
Methods:
Inward rectifying potassium current (IRK) was observed by the whole cell patch-clamp technique.
Results:
IRK was inhibited by Tet in a concentration-dependent manner and recovered to normal after wash with drug-free external solution. IRK was reduced from (582 +/- 48) pA to (221 +/- 40) pA at a holding potential of -70 mV by Tet 30 mumol/L. IC50 was 2.8 mumol/L.
Conclusion:
Tet inhibited inward rectifying potassium current in cultured bovine aortic endothelial cells.
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