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Updated: Aug 9, 2026
13:50
Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
Infected joint replacements in HIV-positive patients with haemophilia
J L Hicks1, W J Ribbans, B Buzzard
1Northampton General Hospital NHS Trust, Cliftonville, England.
The Journal of Bone and Joint Surgery. British Volume
|October 18, 2001
Summary
Joint replacement surgery in patients with human immunodeficiency virus (HIV) is uncommon. While complications like deep sepsis are high (18.7% primary, 36.3% revision), most patients experience significant long-term symptomatic relief.
Area of Science:
- Orthopedic surgery
- Infectious diseases
- Immunology
Background:
- Joint replacement in human immunodeficiency virus (HIV)-positive patients is infrequently performed.
- Existing data primarily comes from patients with hemophilia.
Purpose of the Study:
- To analyze the outcomes of joint replacement surgeries in HIV-positive patients.
- To assess complication rates, particularly deep sepsis, and long-term benefits.
Main Methods:
- Retrospective analysis of 102 joint replacement arthroplasties in 73 HIV-positive patients.
- Data collected from eight specialist hemophilia centers.
- Follow-up duration of five years.
Main Results:
- High rates of deep sepsis observed: 18.7% for primary procedures and 36.3% for revisions.
- Significantly higher infection rates compared to the general population.
- 44% of infections resolved with treatment.
- Survivorship analysis indicates long-term symptomatic relief for most patients.
Conclusions:
- Despite high infection rates, joint replacement offers significant symptomatic relief for HIV-positive patients.
- Careful patient and healthcare worker counseling regarding risks and benefits is essential prior to surgery.
- Further research into optimizing surgical outcomes in this population is warranted.
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