Spontaneous recovery from hypopituitarism in a man with lymphocytic hypophysitis: a case report
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Updated: Oct 4, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
H Noto1, K Tsukamoto, S Hayashi
1Department of Diabetes and Metabolism, Tokyo University Hospital, Japan.
Abstract:
A 50-year-old man presented with hypopituitarism and a pituitary lesion on magnetic resonance imaging scan. He was diagnosed as having lymphocytic hypophysitis, and replacement therapy with hydrocortisone and thyroxine was started. He regained normal pituitary function after 10 months. Reports of spontaneous recovery from lymphocytic hypophysitis in men are rare. While the natural history of lymphocytic hypophysitis remains elusive and its management is not well established, our report shows that spontaneous resolution may occur with steroid supplementation even in men.
