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Pressurized metered dose inhalers and add-on devices
1Department of Cardiovascular and Respiratory Sciences, University La Sapienza, Rome, Italy. cterzano@tin.it
Pulmonary Pharmacology & Therapeutics
|October 18, 2001
Summary
Metered dose inhalers (MDIs) offer a reliable, cost-effective, and portable method for aerosol therapy in treating reversible airflow obstruction. Their versatility is enhanced with add-on devices, improving drug delivery and patient outcomes.
Area of Science:
- Pulmonary Medicine
- Pharmacology
- Biomedical Engineering
Background:
- Metered dose inhalers (MDIs) have significantly advanced aerosol therapy for reversible airflow obstruction in all age groups.
- MDIs are recognized as the gold standard due to their reliability, ease of use, and cost-effectiveness.
Purpose of the Study:
- To review the advancements in metered dose inhaler technology for aerosol therapy.
- To discuss the relationship between particle size and drug deposition in the lower respiratory tract.
- To explore the role of add-on devices and proper inhalation technique.
Main Methods:
- Review of current literature on metered dose inhalers and aerosol therapy.
- Analysis of particle size-drug deposition relationships.
- Discussion of new technologies and propellants.
Main Results:
- MDIs provide reproducible, effort-independent dosing and protect medication from environmental factors.
- Add-on devices increase the versatility of MDIs for diverse patient needs and therapeutic goals.
- Understanding particle size is crucial for targeted drug delivery to the lower respiratory tract.
Conclusions:
- Metered dose inhalers, especially with add-on devices, represent a versatile and efficient aerosol therapy system.
- Proper patient training and understanding of drug delivery dynamics are essential for optimal treatment outcomes.
- New technologies and environmentally friendly propellants are advancing MDI capabilities.