Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unwebbing the presynaptic web.

P L Zamorano1, C C Garner

  • 1Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Neuron
|October 18, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome.

British journal of pharmacology·2013
Same author

Role of Excitatory Amino Acid Neurotransmission during Puberty in the Female Rat.

Molecular and cellular neurosciences·2009
Same author

Presence of NMDA Receptor mRNA in the Anterior Pituitary of the Female Rat: Steroid Modulation and Changes during Gonadotropin Surge Induction.

Molecular and cellular neurosciences·2009
Same author

Subcellular redistribution of the synapse-associated proteins PSD-95 and SAP97 in animal models of Parkinson's disease and L-DOPA-induced dyskinesia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2005
Same author

MAGUKs in synapse assembly and function: an emerging view.

Cellular and molecular life sciences : CMLS·2004
Same author

Principles of glutamatergic synapse formation: seeing the forest for the trees.

Current opinion in neurobiology·2001
Same journal

Dynamic coordination and segregation mechanisms in higher cortex for parallel task processing.

Neuron·2026
Same journal

Higher-order thalamic bursts are drivers of attention control.

Neuron·2026
Same journal

Composing trajectories for rapid inference of navigational goals.

Neuron·2026
Same journal

Peri-head distance coding in the mouse brainstem.

Neuron·2026
Same journal

A two-timepoint framework for sensitive and specific single-cell activity screening.

Neuron·2026
Same journal

From first impressions to bonds: The neural dynamics of social relationships.

Neuron·2026
See all related articles

Researchers purified the presynaptic web, a protein matrix at nerve active zones. This structure contains key proteins essential for synaptic vesicle docking, fusion, and recycling during neurotransmitter release.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Neurotransmitter release is crucial for neuronal communication, occurring at specialized active zones on presynaptic terminals.
  • The presynaptic web, a protein complex near the active zone, is hypothesized to regulate neurotransmitter release sites.

Discussion:

  • Phillips et al. successfully developed methods for biochemical purification of the presynaptic web.
  • This purification allowed for detailed proteomic analysis of the web's composition.

Key Insights:

  • The presynaptic web is composed of proteins directly involved in synaptic vesicle trafficking.
  • Identified proteins play critical roles in vesicle docking, membrane fusion, and subsequent vesicle recycling.

Outlook:

Related Experiment Videos

  • Understanding the presynaptic web's composition provides insights into the precise mechanisms of synaptic transmission.
  • Further research can explore how the web's structure and protein content are regulated.
  • This work lays the foundation for investigating synaptic dysfunction in neurological disorders.