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High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
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High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

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[Multidrug-resistant and fluoroquinolone-resistant Salmonella enterica serotype Typhimurium definitive phage type 12

H Nakaya1, A Yasuhara, K Yoshimura

  • 1Department of Clinical Center Laboratory, Kansai Medical University.

Kansenshogaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
|October 19, 2001
PubMed

Insights

A multidrug-resistant Salmonella Typhimurium strain resistant to fluoroquinolones caused severe infant illness. Fosfomycin successfully treated the infection, highlighting the need for surveillance of resistant Salmonella strains.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Salmonella serotype Typhimurium is a common cause of bacterial gastroenteritis.
  • The emergence of antimicrobial resistance in Salmonella poses a significant public health threat.
  • Fluoroquinolones are critical antibiotics for treating invasive Salmonella infections.

Observation:

  • A 35-day-old infant presented with severe symptoms including high fever, vomiting, and diarrhea.
  • Stool cultures identified a multidrug-resistant Salmonella serotype Typhimurium (phage type DT12).
  • The isolate exhibited resistance to multiple antibiotics, including all tested fluoroquinolones.

Findings:

  • The infant's infection was successfully treated with fosfomycin (MIC <= 1 microgram/ml).
  • The specific route of infection could not be determined.
  • This case highlights the challenge of treating infections caused by extensively drug-resistant bacteria.

Implications:

  • Fosfomycin demonstrates efficacy against fluoroquinolone-resistant Salmonella Typhimurium.
  • Enhanced domestic surveillance for fluoroquinolone-resistant Salmonella is crucial.
  • This case underscores the importance of antimicrobial stewardship and monitoring resistance patterns.

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