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Cowden's disease with vocal fold involvement.

E W To¹, W M Tsang, M W Pak

¹Division of Head and Neck/Plastic and Reconstructive Surgery, Department of Surgery, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR. edwardto@cuhk.edu.hk

Ear, Nose, & Throat Journal

|October 19, 2001

Summary

This case report details Cowden's disease, a rare genetic disorder, in a 47-year-old man. It highlights the first documented instance of vocal fold involvement in this condition, emphasizing its varied mucocutaneous manifestations.

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Area of Science:

Otolaryngology
Dermatology
Genetics

Background:

Cowden's disease is a rare hereditary disorder.
It is characterized by oropharyngeal fibrosis and multiple hamartomas.
These hamartomas have the potential for malignant transformation.

Observation:

A 47-year-old male patient presented with fibrotic lesions on the left vocal fold.
The patient also exhibited extensive papillomatous lesions on the lips, tongue, pharyngeal wall, axillae, and buttocks.
Histopathologic examination confirmed the mucocutaneous lesions were diagnostic of Cowden's disease.

Findings:

This case represents the first reported instance of Cowden's disease affecting the vocal fold.
The findings underscore the diverse mucocutaneous presentations of Cowden's disease.

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Implications:

Early diagnosis and management of Cowden's disease are crucial due to malignant potential.
Vocal fold involvement should be considered in the differential diagnosis of unexplained laryngeal lesions.
This case expands the known spectrum of Cowden's disease manifestations.