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Alkylation of 2-phenyl-4-quinolones: synthetic and structural studies
M Hadjeri1, A M Mariotte, A Boumendjel
1Laboratory of pharmacognosy, UMR-UNRS 5063, Grenoble pharmacy school 3870 La Tornche, France.
Chemical & Pharmaceutical Bulletin
|October 19, 2001
Abstract:
The alkylation of 2-phenyl-4-quinolones was investigated and showed that the N-alkylation versus O-alkylation is highly dependent on whether C-5 is hydroxylated or not. N-Alkylation is favoured by the presence of a 5-hydroxyl group. The synthetic and the NMR structural studies are reported.