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Pemphigus foliaceus developing after metastasis of cutaneous squamous cell carcinoma to regional lymph nodes
1Department of Dermatology, Kanazawa University School of Medicine, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. inaoki-m@med.kanazawa-u.ac.jp
Abstract:
We describe a patient in whom pemphigus foliaceus developed after cutaneous squamous cell carcinoma (SCC) metastasized to regional lymph nodes. Immunologic analysis revealed that production of anti-desmoglein 1 autoantibodies started when SCC metastasized, and the SCC expressed desmoglein 1, suggesting a pathogenic role of metastasized SCC in developing pemphigus foliaceus.
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