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Delayed hypersensitivity in patients with bronchial carcinoma
Scandinavian Journal of Respiratory Diseases
|September 1, 1975
Summary
Cell-mediated immunity, measured by dinitrochlorobenzene skin tests, is suppressed in bronchial carcinoma patients, correlating with a poor prognosis. Tuberculin reactivity, indicating immune memory, remained unchanged and unrelated to patient outcomes.
Area of Science:
- Immunology
- Oncology
- Pulmonology
Background:
- Delayed hypersensitivity skin tests assess cell-mediated immunity.
- Bronchial carcinoma can impact the immune system's function.
- Assessing immune status may offer prognostic insights.
Purpose of the Study:
- To evaluate cell-mediated immunity in patients with bronchial carcinoma.
- To investigate the relationship between immune responses and prognosis in these patients.
Main Methods:
- Administered dinitrochlorobenzene (DNCB) skin tests to assess newly induced cell-mediated immunity.
- Administered tuberculin skin tests to assess immune memory.
- Correlated skin test results with patient prognosis.
Main Results:
- Dinitrochlorobenzene (DNCB) reactivity was suppressed in patients with bronchial carcinoma.
- This suppression of DNCB reactivity was significantly associated with a poor prognosis.
- Tuberculin reactivity was not altered and showed no correlation with prognosis.
Conclusions:
- Suppressed dinitrochlorobenzene (DNCB) reactivity indicates a compromised cell-mediated immune response in bronchial carcinoma.
- Immune suppression, specifically in newly induced responses, is a potential negative prognostic marker.
- Immune memory, as assessed by tuberculin reactivity, is not a reliable prognostic indicator in this context.