The "letter... to a cypriot physician" attributed to Johannes Argyropoulos (ca. 1448-1453)

In four Byzantine medical manuscripts, appears a letter entitled Solution of some problems and questions studied by one among the philosophers and physicians of the [school] of Cyprus and attributed to the well known philosopher and teacher Ioannes Argyropoulos (1393/4 [?] or ca. 1415 - 1487). In this paper, we examine this text, its authenticity and its contents, arriving at the conclusion that it is a sort of compendium of a medical teaching held by Argyropoulos during his stay in Constantinople, ca. 1448 - 1453. As such, it documents the medical activity of the last Byzantine period, little known from other sources.