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Related Experiment Videos

Cannabinols and feeding in sheep.

C L McLaughlin, C A Baile, P E Bender

    Psychopharmacology
    |September 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Cannabinoids, like tetrahydrocannabinol (THC), have varied effects on appetite. This study found that the l-isomer of THC and 9-AC increased food intake in sheep initially, but decreased it later.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Animal Behavior

    Background:

    • Cannabinoids are known to affect appetite, with conflicting results in humans and laboratory animals.
    • Sheep are sensitive to chemical agents influencing food intake, making them a suitable model.

    Purpose of the Study:

    • To investigate the effects of tetrahydrocannabinol (THC) isomers and 9-aza-cannabinol (9-AC) on feeding behavior in sheep.

    Main Methods:

    • Intravenous injections of d- and l-isomers of tetrahydrocannabinol and 9-aza-cannabinol (9-AC) were administered to sheep.
    • Feeding behavior and food intake were monitored over 30 minutes and 24 hours post-injection.

    Main Results:

    • The l-isomer of THC and 9-AC increased food intake within the first 30 minutes.

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  • D-delta 9-THC did not affect food intake in the initial period.
  • After 24 hours, all tested compounds (d- and l-delta 9-THC, and 9-AC) decreased feed intake at certain doses.
  • The l-isomer demonstrated activity at significantly lower doses than typically used in other animal models.

    • Conclusions:

    • Cannabinoid isomers and 9-AC exhibit dose- and time-dependent effects on appetite regulation in sheep.
    • The l-isomer of THC is particularly potent, showing effects at low doses.
    • These findings highlight the complex role of cannabinoids in modulating feeding behavior, with species-specific and isomer-dependent variations.