Intraindividual variability in maximal expiratory flow-volume and closing volume in asymptomatic subjects

The variability of the parameters derived from analysis of the forced vital capacity and the expired nitrogen trace after a vital capacity inhalation of oxygen (closing volume) within a day, from day to day, and from week to week, has been determined. Effort-dependent tests as vital capacity and peak expiratory flow showed the least variability. The greatest variability was seen in effort-independent tests of function such as the maximal expiratory flow rate at 25 per cent (75 per cent of expired vital capacity) and 50 per cent of vital capacity, as well as closing volume. The degree of variability in the tests used was uninfluenced by the periodicity of the tests or the age or smoking habits of the subjects tested. It is suggested that variability of tests of respiratory function should be taken into account in their interpretation.