Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Approaching tolerance in transplantation.

H Waldmann1, S Cobbold

  • 1Sir William Dunn School of Pathology, Oxford, UK. herman.waldmann@path.ox.ac.uk

International Archives of Allergy and Immunology
|October 20, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transplantation tolerance: the big picture. Where do we stand, where should we go?

Clinical and experimental immunology·2017
Same author

Remission Induction in Patients with Lymphoid Malignancies Using Unconjugated CAMPATH-1 Monoclonal Antibodies.

Leukemia & lymphoma·2016
Same author

Limiting dilution analysis of the cells of immune system I. The clonal basis of the immune response.

Immunology today·2014
Same author

Limiting dilution analysis of cells of the immune system II: What can be learnt?

Immunology today·2014
Same author

Advantages of rat monoclonal antibodies.

Immunology today·2014
Same author

An oxidation-labile traceless linker for solid-phase synthesis.

Angewandte Chemie (International ed. in English)·2014
Same journal

Differences in Reported Anaphylaxis Associated With Common Nonsteroidal Anti-inflammatory Drugs: A Pharmacovigilance Study.

International archives of allergy and immunology·2026
Same journal

Association of Serum Galectin-3 Binding Protein with Acute Exacerbation, Inflammation, and Airway Remodeling in Pediatric Asthma.

International archives of allergy and immunology·2026
Same journal

Effectiveness of a Provincial Law to Improve Epinephrine Use for Anaphylaxis in Schools in Alberta, Canada: A Pre-Post Study.

International archives of allergy and immunology·2026
Same journal

Rab27 a regulates dendritic cell immune tolerogenic capacity.

International archives of allergy and immunology·2026
Same journal

Burden of Hereditary Angioedema in Adults: Impact of Disease and Patient Characteristics.

International archives of allergy and immunology·2026
Same journal

Predictors of Treatment Response to Omalizumab in Children with Chronic Spontaneous Urticaria: A Real World Study.

International archives of allergy and immunology·2026
See all related articles

Harnessing immune tolerance for organ transplants is promising but complex. Simpler, cost-effective protocols, possibly combining short-term tolerance induction with maintenance drugs, may offer a practical solution for graft survival.

Area of Science:

  • Immunology
  • Transplantation Science
  • Regenerative Medicine

Background:

  • Basic research shows potential for immune tolerance in organ transplantation.
  • Achieving robust tolerance via mixed chimerism is complex and carries risks.
  • Regulatory tolerance may be easier to induce but lacks long-term stability.

Purpose of the Study:

  • To explore practical and patient-centric approaches to achieving successful organ transplants.
  • To evaluate protocols balancing tolerance induction with graft survival assurance.
  • To identify simple, cost-effective, and compliant strategies for long-term graft function.

Main Methods:

  • Review of current research on immune tolerance induction strategies.
  • Analysis of the feasibility and risks associated with mixed chimerism.

Related Experiment Videos

  • Consideration of regulatory tolerance mechanisms and their limitations.

    • Main Results:

    • Mixed chimerism, while elegant, presents significant procedural complexity and risk.
    • Tolerance induction through regulation may not be sufficiently robust for sustained graft acceptance.
    • Pragmatic protocols prioritize simplicity, cost-effectiveness, and patient compliance over absolute drug-free tolerance.

    Conclusions:

    • A hybrid approach combining short-term tolerance induction with manageable immunosuppressive maintenance therapy is a viable strategy.
    • The ultimate goal is not necessarily complete drug-free tolerance, but a trouble-free, functional graft.
    • Patient assurance of graft survival and function is paramount, potentially outweighing the ideal of complete immune tolerance.