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Published on: January 17, 2018
Radiation-induced meningiomas involving the orbit
S Y Jew1, G B Bartley, D R Salomao
1Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Purpose:
To review the clinical features and outcomes of patients with radiation-induced meningiomas involving the orbit.
Design:
Retrospective case series.
Participants:
Eight patients with radiation-induced meningiomas affecting the orbit.
Methods:
Clinical and pathologic data of the patients were reviewed.
Main Outcome Measures:
Age at diagnosis, mean interval between radiation therapy and meningioma diagnosis, tumor recurrence, histologic atypia, and mean follow-up time after initial diagnosis.
Results:
The mean age at diagnosis was 42 years (range, 21 years to 70 years). The mean interval between radiation therapy and meningioma diagnosis was 26 years (range, 3 years to 54 years). All patients underwent gross total resection or subtotal resection of the meningioma. Five tumors (62.5%) recurred, based on clinical findings and CT imaging. The mean interval between resection of the meningioma and recurrence was 3 years (range, 9 months to 9 years). Three patients (37.5%) had atypical meningiomas. One patient (12.5%) had multiple tumors. The mean follow-up interval was 7 years after initial diagnosis of the meningioma (range, 15 months to 19 years).
Conclusions:
This series of radiation-induced meningiomas, the first in the ophthalmic literature, illustrates the aggressive nature of this tumor.
